RECOVERING REARRANGED CANCER CHROMOSOMES FROM KARYOTYPE GRAPHS

Recovering rearranged cancer chromosomes from karyotype graphs

Abstract Background Many cancer genomes are Mario Lopez extensively rearranged with highly aberrant chromosomal karyotypes.Structural and copy number variations in cancer genomes can be determined via abnormal mapping of sequenced reads to the reference genome.Recently it became possible to reconcile both of these types of large-scale variations in

read more

Hydrogel platform facilitating astrocytic differentiation through cell mechanosensing and YAP-mediated transcription

Astrocytes are multifunctional glial cells that are essential for brain functioning.Most existing methods to induce astrocytes from stem cells are inefficient, requiring couples of weeks.Here, we designed an alginate hydrogel-based method to realize high-efficiency astrocytic differentiation from human neural stem cells.Comparing to the conventiona

read more


A Service-Based Selfish Routing for Mobile Social Networks

Routing in mobile social networks is a challenging task due to the characteristic of intermittent connectivity, especially when the nodes BOTTOMS behave selfishly in real world.Selfish behaviors of node always influence its altruism to provide forwarding service for others and degrade network performance strongly.In this paper, to address the selfi

read more